Five’s plan for the Umbrella siblings to escape the apocalypse by going into the past ends up scattering them throughout different years of Dallas in the 1960s. They manage okay on their own until shortly after 11/22/63, when secondary effects from changes to the timeline cause a nuclear holocaust that can be averted only by recently arrived Five jumping back to 11/15/63 to exert his unique charm into getting the gang to work together.

After stopping the JFK-induced apocalypse in Season 2, the six Umbrella siblings return to 2019 where they no longer exist and their still-living father has founded The Sparrow Academy in their stead.