Five’s plan for the Umbrella siblings to escape the apocalypse by going into the past ends
up scattering them throughout different years of Dallas in the 1960s. They manage okay on
their own until shortly after 11/22/63, when secondary effects from changes to the timeline
cause a nuclear holocaust that can be averted only by recently arrived Five jumping back to
11/15/63 to exert his unique charm into getting the gang to work together.
— Michael Main